Retinoids Help Normalize KeratinizationAlthough the mechanism by which topical and systemic retinoids help restore acne follicles to a healthy state is unknown, it has been well demonstrated that they normalize keratinization within the infundibular region of the follicle, so that shed follicular cells slough to the surface of the skin rather than clump together and obstruct the pores.After exposure to retinoids, follicular cells actually turn over more rapidly than they would in a pre-acne state.Retinoic acid has a high affinity for the gamma retinoid receptors, which are believed to be integral to the pathogenesis of acne.In addition to their ability to reverse abnormal keratinization within the follicle, the topical retinoids - especially adapalene (Differin®), a naphthoic acid derivative - may have anti-inflammatory properties and thus may address two factors involved in the development of acne.
The main reason that many of us look for a miracle cure for acne is because we cannot tolerate acne. If it is severe, we want to get rid of it right now. It makes us feel very bad. Our confidence is affected because of acne. Modern medicine has tested acne treatment but all of them take weeks to show effect. That frustrates us and we require a quick cure. This makes us search for miracle cures.
In our society, there is no shortage of advice. Acne is no different. Following advice such as "don't eat pizza", "Wash your face many times", "avoid oily food" are just plain useless and have no truth in them having helped clear acne.
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